OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteo. Cartl. 27(11).
Evaluation of clinically relevant states in patient reported outcomes in knee and hip osteoarthritis: the patient acceptable symptom state
Tubach, F., Ravaud, P., Baron, G., Falissard, B., Logeart, I., Bellamy, N. (2005) Ann. Rheum. Dis. 64(1): 34–7.
pass pain score estimated
Knee OA patients consider themselves pain-free when they report VAS scores of 32.3 mm or lower.
patients globally well below certain score
Knee OA patients consider themselves well overall at VAS scores of 31.0 mm or lower.
WOMAC score associated with adequate function
Knee OA patients consider their knee function sufficient at WOMAC scores of 31.0 or lower.
A prospective cohort study used three patient reported outcomes typical in trials for osteoarthritis (OA) to estimate the patient acceptable symptom state (PASS), which is the value at which patients consider themselves well. Participants included 1362 outpatients with knee or hip OA who reported a minimum VAS pain score at the beginning of the study and required treatment with a non-steroidal anti-inflammatory drug (NSAID). At a baseline visit and a visit four weeks after starting NSAID treatment, participants reported on their pain, global assessment of disease activity, and functional impairment. At their final visit, patients also reported whether they found their current state satisfactory.
For each of the outcome measures, PASS estimates were stratified into a low, intermediate, or high group based on the patients’ initial scores. For knee OA, patients in the intermediate grouping considered themselves pain-free if they scored below 32.3 on the 0–100 mm visual analog scale (VAS). For other outcomes, PASS scores and their 95% confidence intervals are reported in Table 3. PASS estimates did not vary across age, sex, or duration of disease.