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Research Summary

Intentional weight loss for overweight and obese knee osteoarthritis patients: is more better?

Messier, S.P., Resnik, A.E., Beavers, D.P., Mihalko, S.L., Miller, G.D., Nicklas, B.J., DeVita, P., Hunter, D.J., Lyles, M.F., Eckstein, F., Guermazi, A., and Loeser, R. F. (2018) Arthritis Care Res. (Hobokin). 70(11): 1569–1575.

Key Findings

Clear Dose response

Greater amounts of weight loss (over 10%) resulted in greater clinical and mechanistic outcomes.

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10% weight loss recommended

Evidence suggests minimum 10% weight loss as standard of care for older, overweight or obese adults with knee OA.

range of benefits

Weight loss resulted in improvements across multiple measures, including pain, function, and quality of life.

A secondary analysis of two diet groups from a randomized clinical trial (Intensive Diet and Exercise for Arthritis) was conducted to determine dose responses to weight loss in obese and overweight participants with knee osteoarthritis (OA). After 18 months of weight loss, participants were divided into groups based on their achieved weight loss (below 5%, 5–10%, 10–20%, and over 20%). Participants were then evaluated for clinical and mechanistic outcomes including pain, function, physical and mental quality of life (HRQL), and knee joint compressive force.

Weight loss resulted in significant dose responses for pain, function, HRQL, knee joint compressive force, and other measured outcomes. Participants who achieved more weight loss had greater improvements in the measures, with the over 20% group reporting 25% less pain and better function than the 10–20% group. However, the study was limited by the small sample size in the over 20% weight loss group. Researchers concluded that older, overweight and obese adults with knee OA should lose at least 10% of their weight to experience clinically meaningful improvements in wellbeing.

Relevance to levitation

For overweight and obese patients with OA, this study demonstrates weight loss as an effective intervention resulting in improvements to multiple clinical and mechanistic measures. However, as this study also notes, achieving and maintaining weight loss can be challenging for patients for a variety of reasons, including slowed metabolic rate and feelings of starvation.

As a tri-compartment unloader with a powerful leg extension assist, Levitation may serve as a viable alternative to weight loss or valuable support for sustained weight loss efforts. Proven to reduce joint loads equivalent to 45 lb of weight loss 1– Budarick, A.R. et al. (2020). J. Biomech. Eng. 142(1), Levitation may provide patients with outcomes similar to weight loss or enable them to achieve additional weight loss through improvements to their levels of knee pain, function, and physical activity levels 2– Budarick, A.R. et al. (2020) J. Prosthet. Orthot. Under Peer Review..

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