More Resources

Bannuru et al. (2019)

OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteo. Cartl. 27(11).

Binkley et al. (1999)

The Lower Extremity Functional Scale (LEFS): scale development, measurement properties, and clinical application. Phys. Ther. 79(4).

Cherian et al. (2015)

Strength and functional improvement using pneumatic brace with extension assist for end-stage knee osteoarthritis: a prospective, randomized trial. J. Arthroplasty. 30(5).

Duncan et al. (2006)

Prevalence of radiographic osteoarthritis – it all depends on your point of view. Rheum. 45(6)

Hart et al. (2017)

The prevalence of radiographic and MRI-defined patellofemoral osteoarthritis and structural pathology: a systematic review and meta-analysis. B. J. Sports Med. 51(16).

Heekin & Fokin (2014)

Incidence of bicompartmental osteoarthritis in patients undergoing total and unicompartmental knee arthroplasty: is the time ripe for a less radical treatment?. J. Knee Surg. 27(1).

Jevsevar (2013)

Treatment of osteoarthritis of the knee: evidence-based guideline, 2nd edition. J. Am. Acad. Orthop. Surg. 21(9).

Messier et al. (2018)

Intentional weight loss in overweight and obese patients with knee osteoarthritis: is more better? Arthritis Care Res. (Hobokin) 70(11).

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Research Summary

OARSI Guidelines for the Non-surgical management of knee osteoarthritis

McAlindon, T.E., Bannuru, R.R., Sullivan, M.C., Arden, N.K., Berenbaum, F., Bierma-Zeinstra, S.M., Hawker, G.A., Henrotin, Y., Hunter, D.J., Kawaguchi, H., Kwoh, K., Lohmander, S., Rannou, F., Roos, E.M., Underwood, M. (2014). Osteo. Cart. 22(3): 363-88. doi: 10.1016/j.joca.2014.01.003.

Key Findings

The Osteoarthritis Guidelines Development Group, a group of thirteen medical experts and one patient representative, developed expert consensus guidelines for the non-surgical management of knee osteoarthritis (OA) based on their evaluations of quality-controlled evidence for 29 treatment modalities. Treatment recommendations were categorized as Appropriate, Uncertain, or Not Appropriate, and given scores to represent risk and benefit. In an effort to accommodate a range of health profiles among patients, treatments were either recognized as a Core Treatment viable for all comorbidities or assigned to one of four sub-phenotypes.

Treatments for knee OA that were recognized as Appropriate included biomechanical interventions, intra-articular corticosteroids, exercise, self-management and education, strength training, and weight management.

Relevance to Levitation

Unlike many OA knee braces, Levitation is a tri-compartment unloader with a powerful knee extension assist and is supported by research efforts that are still ongoing. Due to its capacity to unload the entire knee, Levitation can provide substantial knee pain relief to patients with multicompartmental or patellofemoral OA 1– Budarick, A.R. et al. (2020). J. Biomech. Eng. 142(1)
– Bishop, E.L. et al. (2020) Osteo. Cart. Under Peer Review. 28: S243-S244
and increased physical activity 2– Budarick, A.R. et al. (2020) J. Prosthet. Orthot. Under Peer Review..

Additionally, Levitation can support users in implementing the recommended first line treatments of exercise and weight management. Due to its demonstrated ability to reduce pain, improve function, and increase physical activity levels 3– Budarick, A.R. et al. (2020) J. Prosthet. Orthot. Under Peer Review., Levitation can help patients lead more active lifestyles.

Levitation has also been shown to reduce joint loads by an amount equivalent to 45 lb of weight loss 4– Budarick, A.R. et al. (2020). J. Biomech. Eng. 142(1), which is a clinically meaningful amount of weight loss 5– Messier, S.P. et al. (2018) Arthritis Care Res. (Hobokin) 70(11): 1569–1575. As a result, Levitation may provide patients with outcomes similar to weight loss or help them achieve additional weight loss by improving their mobility and activity levels 6– Budarick, A.R. et al. (2020) J. Prosthet. Orthot. Under Peer Review..

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